Scheme 1
Schematic illustration of Trypsin@PSA Gel-mediated proteolytic enzyme therapy. (A) Lava-inspired proteolytic enzyme therapy with Trypsin@PSA Gel improved tumor distribution and penetration of liposomes. (B) Formation of Trypsin@PSA Gel. Trypsin facilitates the gelation of PEG-SH and AgNO3 based on Ag-S bonds. (C) Overall effects of trypsin on tumor cells and tissues include down-regulating ECM-receptor interaction, lysosome function, N-glycan biosynthesis, ribosome biogenesis, and improving antitumor immunity